Uricase For Fast Uric Acid Control
August 22, 2020
enzymes.bio is stabilized by Arg 176 and Gln 228 of the enzyme. Oxygen will subsequently accept an electron pair from the uric acid dianion and be transformed to hydrogen peroxide, which is changed by water that performs a nucleophilic attack on the intermediate to supply 5-hydroxyisourate. Pegloticase should not be used in combination with oral ULT and in patients with glucose-6-phosphate dehydrogenase defici
